The Clinical Efficacy and Impact on Inflammatory Factors of Shenling Baizhu Powder Combined with Anti-Tuberculosis Drugs in Patients with Multidrug-Resistant Pulmonary Tuberculosis of Qi-Yin Deficiency Type
WANG Guiqin
GUO Meifeng
NI Leilei
ZHANG Xinyuan
ZHANG Guojing
XU Shujun
LI Jihan
Abstract：Objective To evaluate the clinical efficacy of modified Shenling Baizhu San combined with anti-tuberculosis drugs on patients with multidrug-resistant tuberculosis(MDR-TB)and a Qi-Yin deficiency constitution,as well as its effects on inflammatory factors.Methods A retrospective analysis was conducted on the medical records of 120 patients with MDR-TB treated at Cangzhou Third Hospital from June 2022 to June 2024.The patients were divided into a control group and an observa-tion group,with 60 patients in each group.The control group received standard treatment for MDR-TB(Bedaquiline+Linezolid+Cycloserine+Clofazimine+Moxifloxacin),while the observation group was additionally treated with modified Shenling Baizhu San.The two groups were compared in terms of traditional Chinese medicine(TCM)symptom scores,lesion absorption rates,spu-tum culture conversion rates,and levels of inflammatory factors[tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP),and interleukin-8(IL-8)].Results After treatment,the TCM symptom scores of the observation group were significantly lower than those of the control group(P＜0.05),and the rates of lesion absorption and sputum culture conversion were significantly higher in the observation group(P＜0.05).Furthermore,the levels of TNF-α,CRP,and IL-8 in the observation group were significantly lower than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Modified Shenling Baizhu San,combined with conventional anti-tuberculosis treatment,can significantly improve the condition of MDR-TB patients with Qi-Yin deficiency by reducing inflammatory factor levels,and it offers better safety.
Keywords：Multidrug-resistant pulmonary tuberculosis(MDR-TB)Deficiency of both Qi and YinShenling Baizhu SanInflammatory factorsClinical efficacy
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1513-1516,1523 )