Study on the Relationship and Diagnostic Efficacy of Serum CXCL16 and CXCR3 Levels with Precancerous Lesions of Gastric Cancer and Gastric Cancer
SHAO Yazhou
Abstract：Objective To investigate the relationship and diagnostic efficacy of serum C-X-C motif chemokine ligand 16(CXCL16)and C-X-C motif chemokine receptor 3(CXCR3)levels in precancerous lesion of gastric cancer(PLGC)and gas-tric cancer(GC).Methods A total of 120 GC patients(GC group)admitted to our hospital from January 2022 to June 2024 were included.Additionally,120 PLGC patients(PLGC group)and 120 healthy volunteers(control group)matched 1∶1 were se-lected.Serum CXCL16 and CXCR3 levels were measured using enzyme-linked immunosorbent assay.Multivariate conditional unordered logistic regression analysis was performed to explore the relationship between serum CXCL16 and CXCR3 levels with PLGC and GC,with gastric lesions as the dependent variable.Receiver operating characteristic(ROC)curves were used to eval-uate the diagnostic efficacy of serum CXCL16 and CXCR3 levels for PLGC and GC.Results Serum CXCL16 and CXCR3 levels were significantly higher in the GC group compared to the PLGC and control groups,and higher in the PLGC group compared to the control group(P＜0.05).After adjusting for Helicobacter pylori infection,family history of cancer,gastrin-17,pepsinogen Ⅰ/pepsinogen Ⅱ,carcinoembryonic antigen,carbohydrate antigen 199,carbohydrate antigen 724,and carbohydrate antigen 125,elevated CXCL16 and CXCR3 levels were identified as independent risk factors for PLGC and GC(P＜0.05).The area under the curve(AUC)for the combined diagnosis of PLGC using serum CXCL16 and CXCR3 levels was 0.913,which was higher than the AUCs for CXCL16(0.845)or CXCR3(0.836)alone(P＜0.05).Similarly,the combined diagnostic AUC for GC was 0.944,exceeding those of CXCL16(0.882)or CXCR3(0.879)alone(P＜0.05).Conclusion El-evated serum CXCL16 and CXCR3 levels are closely associated with the development of PLGC and GC,and their combination demonstrates high diagnostic efficacy for both conditions.
Keywords：Gastric cancerPrecancerous lesion of gastric cancerC-X-C motif chemokine ligand 16C-X-C motif chemokine receptor 3Diagnostic efficiency
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1439-1443,1459 )