Relationship Between Serum Mir-132,Ngf/Trka Pathway Protein Expression and Prognosis in Patients with Spinal Fractures Complicated by Spinal Cord Injury
LU Dingsong
HUA Feng
LI Peng
YANG Suoping
ZHANG Kai
Abstract：Objective To explore the relationship between serum miR-132,nerve growth factor(NGF)/tyrosine protein kinase A(TrKA)pathway protein expression and prognosis in patients with spinal fractures complicated by spinal cord inju-ry(SCI).Methods Patients with spinal fractures who underwent spinal decompression in our hospital from April 2021 to April 2023 were included.A total of 88 patients with SCI were selected as the observation group,and 75 patients with simple spinal fractures were selected as the control group.After one year of postoperative follow-up,the patients in the observation group were divided into a good prognosis group(51 cases)and a poor prognosis group(37 cases)according to different prognosis status.The preoperative serum expression levels of miR-132,NGF,and TrKA were measured,the baseline data of the preop-erative good prognosis group and the poor prognosis group were collected,and the predictive value of serum miR-132,NGF,and TrKA expression for the prognosis of patients with spinal fractures and SCI was evaluated.Results The serum levels of miR-132,NGF,and TrKA in the observation group were higher than those in the control group(P＜0.05),and the levels of the three indicators in the postoperative poor prognosis group were higher than those in the good prognosis group(P＜0.05);patients with spinal canal invasion The rate ≥ 50％,multi-segment SCI,the time from injury to steroid use ≥ 8 hours,and higher serum expression levels of miR-132,NGF,and TrKA are risk factors for prognosis(P＜0.05);miR-13,NGF,TrKA jointly predicts poor postoperative prognosis in patients with spinal injury and SCI,the AUC is 0.889(95％CI:0.820-0.958),the sensitivity is 0.811,and the specificity is 0.843.Conclusion The expression levels of serum miR-13,NGF,and TrKA in patients with spinal injury and SCI are higher than those in patients with simple spinal fracture,and the expres-sion levels of these three indicators with poor prognosis in patients with SCI are higher;the expression levels of serum miR-13,NGF,and TrKA It has good predictive effect on the poor postoperative prognosis of patients with spinal injury and SCI.
Keywords：Spinal fractureSpinal cord injurymiR-132Nerve growth factorTyrosine protein kinase A
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1429-1433 )