The Value of Peripheral Blood SDC-1,ANGPTL4,and FABP4 in Evaluating the Progression and Prognosis of Severe Pneumonia-Related Sepsis Patients
JIANG Yu
ZHANG Shiqing
YUAN Xinyi
Abstract：Objective To explore the value of peripheral blood syndecan-1(SDC-1),angiopoietin-like protein 4(ANGPTL4),and fatty acid-binding protein 4(FABP4)in evaluating the progression and prognosis of severe pneumonia(SP)-related sepsis patients.Methods From July 2022 to July 2024,92 patients diagnosed with SP-induced sepsis in Ji-angning Hospital of Nanjing were included as the study group,and 98 healthy individuals who underwent health check-ups in our hospital were selected as the control group.According to the 30-day survival status,the study group was further divided into the death group(n=41)and the survival group(n=51).The levels of SDC-1,ANGPTL4,and FABP4 in peripheral blood were measured using ELISA.Pearson correlation analysis was used to determine the relationship between SDC-1,ANGPTL4,and FABP4 levels and APACHE Ⅱ scores.Multivariate logistic regression analysis was applied to identify risk factors for poor prog-nosis in SP-induced sepsis patients,and the ROC curve was plotted to evaluate the diagnostic value of SDC-1,ANGPTL4,and FABP4 for prognosis.Results The levels of SDC-1,ANGPTL4,and FABP4 in the study group were signifi-cantly higher than those in the control group(P＜0.05).The death group showed significantly higher peripheral blood levels of SDC-1,ANGPTL4,and FABP4 com-pared to the survival group(P＜0.05).The APACHE Ⅱscore in the death group was also significantly higher than that in the survival group(P＜0.05).Levels of SDC-1,ANGPTL4,and FABP4 were positively correlated with APACHE Ⅱ scores(P＜0.05).Multivariate logistic regression anal-ysis identified SDC-1,ANGPTL4,FABP4,and APACHE Ⅱ scores as risk factors for mortality in SP-induced sepsis patients(P＜0.05).The AUC for combined SDC-1,ANGPTL4,and FABP4 in predicting mortality in SP-induced sepsis patients was 0.980,significantly higher than that of individual markers(Z=3.555,2.630,3.553;P＜0.05).Conclusion Levels of SDC-1,ANGPTL4,and FABP4 in peripheral blood are significantly elevated in SP-induced sepsis patients,and their combination has a certain value for predicting prognosis.They can serve as reliable serological markers for evaluating disease progression and prognosis.
Keywords：Syndecan-1Angiopoietin-like protein 4Fatty acid-binding protein 4Severe pneumoniaSepsisDisease progressionPrognosis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1414-1419 )