Diagnostic Value of Shear Wave Elastography Combined with Serum TG and VEGF Levels for Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Cancer
WANG Dong
PENG Yanyan
FAN Xinxing
LI Xue
WU Linsong
Abstract：Objective To investigate the diagnostic value of shear wave elastography(SWE)combined with serum thyroglobulin(TG)and vascular endothelial growth factor(VEGF)levels in the diagnosis of cervical lymph node metastasis(CLNM)in patients with papillary thyroid carcinoma(PTC).Methods Sixty patients with PTC complicating CLNM admitted to our hospital from January 2022 to January 2024 were selected as the CLNM group,and 60 patients with PTC not complicating CLNM were selected as the non-CLNM group at a 1∶1 ratio.SWE examination was performed to record the Young's modulus maximal(Emax)and minimal(Emin)value,and levels of TG and VEGF were measured.With CLNM in PTC patients as the dependent variable,multifactorial conditional Logistic regression was used to determine its influencing factors,and receiver operating characteristic curves were plotted to analyze the diagnostic value of SWE in combination with serum TG and VEGF levels.Results The levels of Emax,Emin,TG,and VEGF[109.71(82.26,148.95)kPa],[41.63(33.12,50.28)kPa],[21.36(11.69,36.95)ng/mL],and[59.81(40.05,98.25)ng/L]in the CLNM group were higher than those in the non CLNM group[54.42(33.19,82.55)kPa],[32.66(20.04,36.88)kPa],[12.23(7.04,16.49)ng/mL],and[35.61(21.42,50.05)ng/L](Z=-6.162,-5.131,-4.661,and-6.002,all P＜0.05).The independent risk factors for CLNM in PTC patients were envelope invasion(OR=12.182,95％CI:1.844 to 80.470),high Emax(OR=1.057,95％CI:1.024 to 1.091),high Emin(OR=1.125,95％CI:1.040 to 1.218),high TG(OR=1.146,95％CI:1.050 to 1.250),and high VEGF(OR=1.108,95％CI:1.036 to 1.186)(all P＜0.05).The area under the curve of SWE combined with serum TG and VEGF levels to diagnose CLNM in PTC patients was 0.966(95％CI:0.916 to 0.991),which was greater than that of SWE,TG,and VEGF diagnosis of 0.900(95％CI:0.832 to 0.947),0.747(95％CI:0.659 to 0.822),0.777(95％CI:0.692 to 0.848)(Z=2.723,5.002,4.020,all P＜0.05).Conclusion High levels of SWE parameters(Emax and Emin)and serum TG and VEGF are associated with CLNM in patients with PTC,and SWE combined with serum TG and VEGF levels has a high diagnostic value for CLNM in patients with PTC.
Keywords：Papillary thyroid cancerShear wave elastographyThyroglobulinVascular endothelial growth factorCervi-cal lymph node metastasisDiagnostic value
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1385-1390 )