Predictive Value of Saa,Il-6,and Scd14 for the Prognosis of Copd Patients with Pulmonary Infection

ZHANG Hua; LI Yumei; ZHANG Shiping; WU Jing

doi:10.3639/j.issn.2095-3097.2024.09.012

Abstract：Objective To evaluate the predictive efficacy of serum amyloid A(SAA),interleukin-6(IL-6),and soluble cluster of differentiation antigen 14(sCD14)in predicting the prognosis of patients with chronic obstructive pulmonary disease(COPD)complicated by pulmonary infection.Methods One hundred and thirteen COPD patients with pulmonary infection in our hospital from June 2021 to December 2022 were selected,and divided into survival group(n=98)and death group(n=15)according to their prognosis.The clinical data of all patients were collected.Levels of SAA,IL-6 and sCD14 were detected by immunofluorescence assay(IFA)and enzyme-linked immunosorbent assay(ELISA).Factors affecting the prognosis of COPD patients with pulmonary infection were identified using multivariate Logistic regression model,then the value of the separate and combined test of SAA,IL-6 and sCD14 in predicting the prognosis of COPD patients with pulmonary infection was evaluated by plotting receiver operating characteristic(ROC)curve.Results The COPD grade and Global Initiative for Chronic Obstructive Lung Disease(GOLD)classification in death group were higher than those in survival group(P＜0.05).Levels of SAA,IL-6 and sCD14 in survival group were significantly lower than those in death group(P＜0.05).Multivariate Logistic analysis denoted that COPD grade,GOLD classification,SAA,IL-6 and sCD14 levels were all related factors affecting the prognosis of COPD patients with pulmonary infection.The area under the curve(AUC),sensitivity and specificity of combined test of SAA,IL-6 and sCD14 in the prognosis prediction were 0.848,80.0 and 82.7,which were all better than those of individual markexs.Conclusion SAA,IL-6 and sCD14 are of certain value in predicting the prognosis of COPD patients with pulmonary infection,and the combined test obtains the highest predictive value.Furthermore,COPD grade,GOLD classification,SAA,IL-6,and sCD14 levels are all risk factors affecting the prognosis of COPD patients with pulmonary infection.