Diagnostic Value of iLiv Touch Combined with Serum Free Fatty Acid in Non-Alcoholic Fatty Liver Disease
YANG Wenshuai
WANG Likun
DONG Conghui
WU Yongping
SHI Shuanzhu
Abstract：Objective To investigate the diagnostic value of iLiv Touch combined with serum free fatty acid(FFA)in non-alcoholic fatty liver disease(NAFLD).Methods A total of 107 patients with liver pathology and iLiv Touch examination in our hospital from June 2018 to December 2019 were selected and divided into four subgroups according to steatosis severity:S0 group(35 cases),S1 group(25 cases),S2 group(27 cases),S3 group(20 cases).The serum FFA level was detected by enzyme colorimetry and compared between groups;fat attenuation parameters(FAP)were detected by iLiv Touch.The receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum FFA for NAFLD(S ≥ 1),NAFLD(S ≥ 2),and NAFLD(S ≥ 3).If either or both iLiv Touch and FFA re-sults indicated steatosis,the combined diagnostic results were considered positive.Pathological diagnosis served as the gold standard to assess the diagnostic value of iLiv Touch and FFA in NAFLD(S≥1),NAFLD(S ≥ 2),and NAFLD(S ≥ 3).Results Compared with the S0 group,FAP and FFA of S1 group,S2 group,and S3 group were higher(P＜0.05);compared with the S1 group,FAP and FFA of S2 group and S3 group were higher(P＜0.05);compared with the S2 group,FAP and FFA of S3 group were higher(P＜0.05).The sensitivity,specificity,and accuracy of iLiv Touch in the diagnosis of NAFLD(S≥1),NAFLD(S≥2),and NAFLD(S≥3)were 85.71％,77.78％,and 80.37％;88.33％,85.11％,and 86.92％;93.10％,75.00％,and 89.72％,respec-tively.The area under the curve(AUC)of serum FFA in the diagnosis of NAFLD(S ≥ 1),NAFLD(S≥2),and NAFLD(S≥3)were 0.869,0.920,and 0.836;the cut-off values were 0.70 mmol/L,0.89 mmol/L,and 1.13 mmol/L,respectively.The sensitivity,specificity,and accuracy for FFA alone were 74.29％,83.33％,and 80.37％;71.67％,93.62％,and 81.31％;81.61％,75.00％,and 80.37％,respectively.The sensitivity,specificity,and accuracy of iLiv Touch combined with serum FFA for diagnosing NA-FLD(S≥1),NAFLD(S≥2),and NAFLD(S≥3)were 91.43％,70.83％,and 77.57％;93.33％,72.34％,and 87.85％;95.40％,70.00％,and 90.65％,respectively,all of which were higher than the sensitivity of single diagnosis.Conclusion iLiv Touch combined with serum FFA was more sensitive in the diagnosis of NAFLD than either method alone and could be used for grading diagnosis,which might provide clinical reference for follow-up and disease monitoring of NAFLD.
Keywords：Non-alcoholic fatty liver diseaseTransient elastographyFat attenuation parametersFree fatty acidsReceiver operating characteristic curve
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1330-1335 )