Features of Microbial Pathogens Involved in Sexually Transmitted Infections in the Lower Genital Tract of Patients with Cervical Intraepithelial Neoplasia and Their Relationship with HPV Infection

LI Yunfang; GOU Mingyue; SHEN Fuqiang

doi:10.3639/j.issn.2095-3097.2024.09.004

Abstract：Objective To investigate the distribution characteristics of microbial pathogens involved in sexually trans-mitted infections(STIs)in the lower genital tract of patients with different grades of cervical intraepithelial neoplasia(CIN)and its relationship with human papillomavirus(HPV)infection.Methods A total of 102 patients diagnosed with CIN by cervical biopsy in Langfang People's Hospital from March 2022 to March 2024 were selected and divided into CIN Ⅰ group(52 cases),CINⅡ group(31 cases),and CIN Ⅲ group(19 cases)according to CIN classification.The pathogen detection of STIs,HPV genotyping were carried out for each group respectively,and the results were analyzed.Results The infection rate of STIs pathogens in the three groups of CIN patients increased gradually with the group,but the difference was not statistically significant(P＞0.05).The infection rate of different infection types from low to high was single,multiple,and double infection,suggesting that the higher the CIN grade,the higher the STIs infection rate,and mainly mixed infections;There were statistically significant differences in the infection rates of UU,Mh,Mg and double and multiple infections between the HPV-positive and HPV-negative groups(P＜0.05),and there was no statistically significant difference in the infection rates of NG,CT,HSV-Ⅱ and single infection between the two groups(P＞0.05),suggesting that the infections of UU,Mh,Mg and mixed STIs pathogens were consistent with HPV infection;;The infection rates of UU,Mh,Mg and double and multiple infections between the HPV-positive and HPV-negative groups were statistically significant(P＜0.05),suggesting that the infections of UU,Mh,Mg and mixed STIs pathogens were risk factors for HPV infection;There was no statis-tically significant difference in the combined infection rate of STIs pathogens and HPV among the three groups(P＞0.05),suggesting that STIs pathogen infection was not related to the entire pathological process of CIN caused by HPV infection.Conclusion The higher the grade of cervical intraepithelial neoplasia,the higher the infection rate of sexually transmitted microorganisms in the lower genital tract,and STIs are mainly mixed infections.The infections of UU,Mh,Mg and mixed STIs pathogens are risk factors for HPV infection.