Correlation Study of COX-2 and PARP10 Expression with Prognosis in Patients with Gastroenteropancreatic Neuroendocrine Neoplasms
SHEN Xuewen
TANG Qiyun
BAI Jian'an
LI Xiaoya
Abstract：Objective To investigate the relationship between the expression of cyclooxygenase-2(COX-2)and poly(ADP-ribose)polymerases(PARP)10(PARP10)in gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)tissues and their clinicopathological characteristics and prognosis.Methods A total of 122 patients with GEP-NENs treated at the First Affiliated Hospital of Nanjing Medical University from January 2020 to June 2021 were included.Immunohistochemistry was used to detect COX-2 and PARP10 expression in GEP-NENs tissues and corresponding adjacent non-tumor tissues.The rela-tionship between COX-2 and PARP 10 expression and clinicopathological features was analyzed.Kaplan-Meier survival curves were constructed for 3-year survival based on COX-2 and PARP10 expression levels.A Cox regression model was used to ana-lyze prognostic factors affecting GEP-NENs patient outcomes,using prognosis as the dependent variable.Results The posi-tive expression rates of COX-2 and PARP10 in GEP-NENs tissues were significantly higher than in adjacent non-tumor tissues(P＜0.05).COX-2 and PARP 10 expression levels varied significantly with tumor size,TNM stage,pathological grade,lymph node metastasis,and distant metastasis(P＜0.05)but not with gender,age,or tumor location(P＞0.05).During a 3-year fol-low-up,3 patients were lost to follow-up,and the overall 3-year survival rate was 78.15％(93/119).Patients with positive ex-pression of COX-2 and PARP 10 had lower 3-year survival rates[69.88％(58/83)and 69.62％(55/79),respectively]compared to patients with negative expression[97.22％(35/36)and 95.00％(38/40),respectively](P＜0.05).Multivar-iate Cox regression analysis showed that,after adjusting for confounders(tumor size,TNM stage,pathological grade,lymph node metastasis,and distant metastasis),positive expression of COX-2 and PARP 10 were inde-pendent risk factors for mortality in GEP-NENs patients(P＜0.05).Conclusion Elevated expression of COX-2 and PARP10 in GEP-NENs tissues is closely associated with tumor size,TNM stage,pathological grade,lymph node metastasis,distant metastasis,and poor prognosis.
Keywords：Gastroenteropancreatic neuroendocrine neoplasmCyclooxygenase-2Poly(ADP-ribose)polymerase 10Clinicopathological characteristicsPrognosis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1305-1309,1314 )