Analysis of Risk Factors for Effects of Dexmedetomidine Combined Anesthesia on Gastrointestinal Function in Patients Undergoing Colon Cancer Surgery

SHI Xiao; YANG Baozhong

doi:10.3969/j.issn.2095-3097.2024.06.005

Abstract：Objective To investigate the effects of dexmedetomidine combined anesthesia on postoperative gastroin-testinal function in patients with colon cancer and analyze the related risk factors.Methods 147 patients with colon cancer admitted to Taiyuan Hospital of Peking University First Hospital from 1 year 2021 to April 2024 were selected as the study ob-jects for retrospective study.Gastrointestinal intolerance was divided into occurrence group(n=52) and non-occurrence group (n=95) according to the medical record system.The relevant clinical data of patients were collected and compared,col-linearity analysis was carried out for the difference indicators,and indicators without collinearity problems were incorporated into the Logistic regression model to analyze the related influencing factors of postoperative gastrointestinal functional intoler-ance in colon cancer patients.Results There were statistically significant differences in dexmedetomidine dose,anesthesia time,intraoperative blood loss,operative time,intraoperative MAP,and intraoperative HR (t/Z=6.602,6.016,5.337,6.543,5.131,5.567,P<0.05),and there were no collinearity problems in the above indexes (VIF≤10,Tolerance ≥0.1),Logistic regression analysis showed that dexmedetomidine dose,anesthesia time,intraoperative blood loss and operation time were independent risk factors (OR=42.898,1.070,1.007,1.050,P<0.05).Both intraoperative MAP and intraoper-ative HR were negatively correlated with postoperative gastrointestinal intolerance in patients with colon cancer surgery,and were independent protective risk factors (OR=0.853,0.831,P<0.05).Conclusion Anesthesia dose,anesthesia time,anesthesia method,intraoperative blood loss,operation time,and opioid use were all independent influencing factors of post-operative gastrointestinal intolerance in patients with colon cancer.Screening high-risk groups by the above indicators provided theoretical reference for taking appropriate intervention measures before clinical operation to improve prognosis.