Assessment of Eye Surface Symptoms for Patients After Cataract Surgery Using 0.1％ Dexamethasone Drops with and without Preservatives
XIE Yuming
Abstract：Objective To compare the impact of dexamethasone drops with and without preservatives on dry eye symptoms in patients after cataract surgery and to assess their clinical efficacy and safety. Methods A total of 103 patients who received surgical treatment from January to December 2023 were included. All patients underwent phacoemulsification surgery. After surgery,the patients were randomly divided into a treatment group (n=55):receiving 0.1％ dexamethasone disodium phosphate eye drops without preservatives;and a control group (n=58):receiving 0.1％ dexamethasone disodium phosphate eye drops preserved with benzalkonium chloride (BAC). Both groups used the medica-tion four times daily for two weeks. The primary outcome measures were Ocular Surface Disease Index (OSDI),fluorescein tear break-uPtime (FBUT),scores for corneal fluorescein staining,Schirmer test results,and intraocular pressure (IOP). Results Two weeks after surgery,the treatment group showed significant improvement in corneal fluorescein staining scores and IOP. In the control group,only corneal fluorescein staining scores significantly worsened,and IOPremained un-changed. FBUT decreased in both groups after two weeks,but the differences were not statistically significant. The ocular foreign body sensation in the control group significantly increased two weeks after surgery. Conclusion Dexamethasone disodium phosphate eye drops without preservatives were more effective in managing dry eye symptoms in patients after cat-aract surgery,especially in improving corneal fluorescein staining and decreasing IOP. In addition,patients using dexameth-asone drops with preservatives had significantly increased ocular foreign body sensation. This study provides a reference for optimizing drug regimens after surgery and may help improve the postoperative quality of life of patients.
Keywords：CataractDexamethasonePreservativeOcular surface symptomsComparative efficacy study
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 598-600 )