The Application of Nickel-Titanium File with ProTaper in Root Canal Treatment of Molar and Its Influence on MMP-8,MMP-2,and IL-8 Levels in Gingival Fluid
WANG Shichao
LIN Wei
GE Yu
Abstract：Objective To investigate the filling effect of nickel-titanium file with ProTaper in root canal treat-ment (RCT) of molars as well as its impact on matrix metalloproteinase (MMP-8,MMP-2) and interleukin (IL-8) levels in gingival fluid. Methods A total of 80 patients who received molar RCT in Hefei Stomatology Hospital from January 2019 to August 2023 were divided into the study group (ProTaper with nickel-titanium file,n=43) and the control group (stainless steel K file,n=37). Root canal preparation/filling outcomes and changes in MMP-8,MMP-2,and IL-8 levels in gingival fluid were compared between the two groups. Results The study group had significantly shorter root canal preparation time compared to the control group (P<0.05). The filling rate in the study group was significantly higher than in the control group (95.35％ vs 81.08％,P<0.05). There was no significant difference in the rate of good root canal preparation between the two groups (97.67％ vs 86.49％,P>0.05). The levels of MMP-8,MMP-2,and IL-8 in gingival fluid decreased significantly in the study group 72 hours after surgery and were lower than those in the control group (P<0.05). Conclu-sions Nickel-titanium file with ProTaper demonstrated better filling effects than stainless steel K file,significantly short-ening root canal preparation time and reducing MMP-8,MMP-2,and IL-8 levels in gingival fluid.
Keywords：Root canal therapyNickel-titanium file with ProTaperMatrix metalloproteinasesInterleukin-8
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 576-579 )