New Advances in Drug Resistance Mechanism and Molecular Targeted Therapy in Multiple Myeloma:Report on Research Hotspots at the 20th International Society of Myeloma Annual Conference
MA Jingyuan
HAO Mu
Abstract：Objective Multiple myeloma(MM)is a hematologic malignancy characterized by clonal proliferation of malignant plasma cells.Proteasome inhibitors,immunomodulatory drugs and autologous hematopoietic stem cell transplantation have significantly improved the quality of life and survival of MM patients.However,almost all patients will develop drug re-sistance,leading to difficult disease recurrence and poor prognosis.Therefore,it is particularly important to explore the molec-ular mechanism of drug resistance in MM patients,search for new therapeutic targets and develop new targeted therapeutic strategies.This article reviews the recent progress in the research of MM resistance mechanism and molecular targeted thera-py.
Keywords：Multiple myelomaDrug resistanceneoplasmMolecular targeted therapyReviewProteasome inhibi-torsImmunomodulatory drugsVenetoclaxChimeric antigen receptor
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 292-295 )