Effects of Sintillizumab Combined with Paclitaxel and Platinum-based Chemotherapy Drugs in Patients with Advanced Cervical Cancer and Their Effect on Serum Tumor Markers and Immune Function
ZHA Jingjuan
ZHENG Xiaoting
WU Shengbao
Abstract：Objective To investigate the effects of Sindilizumab combined with Paclitaxel and Platinum-based chemo-therapy drugs on advanced cervical cancer,and their effect on serum tumor markers and immune function.Methods A total of 80 patients with advanced cervical cancer admitted to our hospital from June 2020 to June 2023 were selected and divided into the observation group(n =40)and the control group(n =40)according to different treatment methods.The observation group was given Sindilizumab combined with Paclitaxel and Platinum-based chemotherapy drugs,and the control group was given Paclitaxel and Platinum-based chemotherapy drugs.The clinical effect after 4 courses of treatment,tumor markers[car-cinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCC-Ag),tumor sup-plied group of factors(TSGF)],vascular endothelial growth factor(VEGF),transforming growth factor β1(TGF-β1),hu-man leukocyte antigen G(HLA-G),and immune functions[CD4 +,CD3 +,CD4 +/CD8 +]before and after 2 and4 cour-ses of treatment,as well as adverse reactions during treatment,were compared between the two groups.Results The disease control rate(DCR)in the observation group was 82.50%(33/40),which was higher than that in the control group[62.50%(25/40)](P<0.05).CEA,CA125,SCC-Ag,TSGF,VEGF,TGF-β1 and HLA-G in the two groups were lower than those before treatment,which were lower in observation group than in control group after 2 courses of treatment and 4 courses of treatment;CD4 +,CD3 +,and CD4 +/CD8 + in the two groups were lower than those before treatment,which were higher in observation group than in control group(P<0.01,P<0.05).There was no significant difference in total inci-dence of adverse reactions between the two groups(P>0.05).Conclusion Sindelizumab combined with Paclitaxel and Platinum-based chemotherapy drugs has a reliable effect in the treatment of advanced cervical cancer patients,which can down-regulate serum tumor markers and the levels of VEGF,TGF-β1 and HLA-G,stabilize immunity,and do not increase adverse reactions.
Keywords：Uterine cervical neoplasmsAdvancedSindilimabPaclitaxelPlatinumCarcinoembryonic antigenVascular endothelial growth factorCD4 +
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 248-254 )