Distribution Characteristics of Pathogens in Patients with Acute Cerebral Infarction Accompanied by Pulmonary Infection and Their Effects on Bax,FEIR,and GSH-Px Levels
WEN Huan
WANG Di
Abstract：Objective To investigate the distribution characteristics of pathogenic bacteria in patients with acute cere-bral infarction(ACI)and the effect of pulmonary infection on the levels of B-cell lymphoma/leukemia-2 gene associated X protein(Bax),immunosuppressive factor(FEIR)and glutathione peroxidase(GSH-Px).Methods Fifty-three ACI patients with pulmonary infection treated from May 2020 to May 2022 were selected as the research group,and 51 ACI patients without pulmonary infection treated during the same period were selected as the control group.The distribution of pathogenic bacteria in the research group was analyzed,and serum Bax,FEIR and GSH-Px levels were compared between the two groups.Results In the research group,5(9.43%)of the 53 patients were infected with fungi,mainly Candida albicans.There were 24 ca-ses of gram-positive bacteria infection,accounting for45.28%,mainly caused by Staphylococcus aureus,followed by Strepto-coccus pneumoniae.There were 24 cases of gram-negative bacteria infection,accounting for 45.28%,mainly caused by Acine-tobacter baumannii,followed by Escherichia coli and Klebsiella pneumoniae.Serum Bax and FEIR levels in the research group were higher than those in the control group,while GSH-Px levels were lower than those in the control group(P<0.01).Conclusion The pathogenic bacteria of ACI patients with lung infection were mainly gram-positive and gram-negative bacteria,and the oxidative stress level of ACI patients with lung infection was significantly increased,as compared with that of ACI alone.
Keywords：Acute cerebral infarctionPulmonary infectionGlutathione peroxidaseB-cellymphoma-2 associated X proteinImmunosuppressive factorCandida albicansStaphylococcus aureusAcinetobacter baumannii
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 183-186 )