Relationship Between IL-17 and Hcy Expression Levels and Microsatellite Status in Serum and Tissue of Patients with Gastric Cancer
XU Aifang
LIU Zheng
GONG Xiangliang
LI Shilong
SONG Yang
Abstract：Objective To investigate the relationship between the expression levels of interleukin-17(IL-17)and homocysteine(Hcy)and microsatellite status in serum and tissues of patients with gastric cancer.Methods A total of 40 pa-tients with microsatellite stable and low-grade microsatellite unstable gastric cancer treated from March 2020 to March 2022 were selected as the stable group,and another 40 patients with high-grade microsatellite unstable gastric cancer were selected as the unstable group.General data in the two groups were collected,and serum IL-17,Hcy levels,and IL-17 expression lev-els in dissected specimens during the operation were detected.The risk factors of microsatellite status in patients with gastric cancer were analyzed by multivariate Logistic regression analysis.The predictive value of serum IL-17,Hcy and IL-17 levels in the tissue on microsatellite status in patients with gastric cancer was analyzed by receiver operating characteristic(ROC)curve.Results The number of lymphatic metastasis in the unstable group was smaller than that in the stable group(P<0.05).The IL-17 and Hcy levels in serum and tissues in unstable group were lower than those in stable group(P<0.05,P<0.01).Multivariate Logistic regression analysis showed that lymphatic metastasis,serum IL-17,serum Hcy and IL-17 levels in the tissue were all risk factors affecting microsatellite status in patients with gastric cancer(P<0.05,P<0.01).ROC curve analysis showed that the area under the curve,sensitivity and specificity of serum IL-17 and Hcy levels and IL-17 levels in tissue in combination in predicting microsatellite status in patients with gastric cancer were higher than that predicted by single index.Conclusion Lymphatic metastasis,and IL-17 and Hcy levels in serum and tissue are risk factors affecting microsatellite status in patients with gastric cancer,and the combined detection of lymphatic metastasis,and IL-17 and Hcy levels in serum and tissue can better predict microsatellite status in patients with gastric cancer.
Keywords：Stomach neoplasmsInterleukin-17HomocysteineMicrosatellite stateReceiver operating characteris-tic curveAnalysis of influencing factorsDiagnostic effectivenessArea under the curve
Publication Date：2024-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 112-116 )