Short-term Prognostic Value of Serum sTim-3 and Galectin-9 Levels in Continuous Renal Replacement Therapy in Patients with Severe Acute Kid-ney Injury
TANG Bingbing
ZHANG Cuicui
LIU Feng
WEI Hua'nan
LYU Furong
Abstract：Objective To investigate the short-term prognostic value of serum soluble T lymphocyte immunoglobulin mucin-3(sTim-3)and Galectin-9(Galectin-9)in continuous kidney replacement therapy(CRRT)in patients with severe acute kidney injury(AKI).Methods In total,136 patients with severe AKI treated from March 2021 to March 2023 were selected as the research subjects.According to the survival of severe AKI patients within 90 days from CRRT(short-term prognosis),the patients who died were included in the death group(n =42),and the patients who survived were included in the survival group(n =94).The short-term prognostic value of serum sTim-3 and Galectin-9 in patients with severe AKI was evaluated by receiver operating characteristic(ROC)curve,and the factors affecting the short-term prognosis of CRRT in pa-tients with severe AKI were analyzed by multivariate Logistic regression analysis.Results The serum sTim-3 and Galectin-9 in death group were higher than those in survival group(P<0.01).The area under the curve(AUC)of serum sTim-3 and Galectin-9 in predicting the short-term prognosis of CRRT in patients with severe AKI was 0.762 and 0.847,respectively,and the AUC of the combined prediction was 0.914.Multivariate Logistic regression analysis showed that sTim-3≥17.00 ng/L,Galectin-9≥4.00 ng/L,Acute physiological and Chronic health status score system Ⅱ≥20 scores were the risk factors for death within 90 days from CRRT in patients with severe AKI(P<0.05,P<0.01).Conclusion The in-crease of serum sTim-3 and Galectin-9 is closely related to the poor short-term prognosis of CRRT in patients with severe AKI,which can be used as a biological indicator to evaluate the poor short-term prognosis of CRRT in patients with severe AKI,and the combination of the two has higher predictive performance.
Keywords：Acute Kidney InjurySevereContinuous renal replacement therapySoluble T lymphocyte immunoglob-ulin mucin-3Galectin-9PrognosisReceiver operating characteristic curveLogistic regression analysis
Publication Date：2024-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 89-94 )