Effect of Addition or Reduction of Sanbai Yishen Formula in the Adjuvant Treatment of Chronic Nephritis of Spleen-kidney Deficiency Type and Its Effect on 24-hour Urinary Total Protein Quantity and Th17/Treg Cells
CHEN Lixiang
YU Hemei
WANG Chunning
XU Shufen
GAO Fushun
Abstract：Objective To analyze the effect of addition or reduction of Sanbai Yishen decoction in the adjuvant treat-ment of chronic nephritis of spleen-kidney deficiency type and its effect on 24-hour urinary total protein(24 h UTP)and Th17/Treg cells.Methods A total of 100 patients with chronic nephritis of spleen-kidney deficiency type treated from Janu-ary 2020 to January 2022 were selected as the research subjects,and were divided into observation group(n =50)and control group(n =50)according to random number table method.The control group was treated with Irbesartan tablets,and the ob-servation group was treated with addition or reduction of Sanbai Yishen formula and Irbesartan tablets for 2 consecutive months.The efficacy and safety of traditional Chinese medicine were compared between the two groups.In the meantime,the TCM syndrome scores,24 h UPT,renal function indicators[urinary microalbumin/creatinine ratio(ACR),blood urea nitro-gen(BUN),serum creatinine(Scr),cystatin C(CysC)],Th17/Treg cells and their cytokines[interleukin-10(IL-10),interleukin-17(IL-17),interleukin-23(IL-23),transforming growth factor-β1(TGF-β1)]before and after treatment of the two groups were compared.Results At 2 months after treatment,the total effective rate of the observation group was 90.00%(45/50),which was significantly higher than that of the control group[72.00%(36/50)](P<0.05).At 1 and 2 months after treatment,TCM syndrome score,24 h UTP,BUN,Scr,ACR,CysC,Th17/Treg cells and serum levels of IL-17 and IL-23 in observation group were lower than those in control group,while serum levels of TGF-β1 and IL-10 were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The addition and reduction of Sanbai Yishen formula can effectively reduce the24 h UTP in patients with chronic nephritis of spleen-kidney deficiency type and improve the therapeutic effect.The possible mechanism is related to the maintenance of dynamic balance of Th1/Treg cells.
Keywords：Chronic nephritisSanbai Yishen formulaIrbesartan tabletsProteinuriaTh17/Treg cellsInterleukin-10Interleukin-17Transforming growth factor-β1
Publication Date：2023-12-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 374-379 )