Association between Peripheral Blood T Lymphocytopenia and RIG-I Path-way in Patients with Dermatomyositis
ZHANG Zongfang
PANG Jie
LI Yanxia
Abstract：Objective To investigate the association between peripheral blood T lymphocytopenia and retinoic acid-induced gene-I(RIG-I)pathway in patients with dermatomyositis.Methods Sixty patients with dermatomyositis(dermato-myositis group)and 60 normal healthy subjects(control group)were selected from August 2020 to August 2023.The expres-sion levels of T lymphocytes and RIG-I pathway nuclear factor-κB(NF-κB),interferon regulatory factor-3(IRF-3)and inter-feron regulatory factor-7(IRF-7)proteins in peripheral blood and their correlation in the two groups were detected and ana-lyzed.The correlation between peripheral blood T lymphocytes and RIG-I pathway-related proteins was analyzed by Pearson analysis.Results CD4 + T cells,CD8 + T cells,and CD4 +/CD8 + were lower in dermatomyositis group than in control group,while NF-κB protein,IRF-3 protein,IRF-7 protein and RIG-I protein were higher than those in control group(P<0.01).CD4 + T cells,CD8 + T cells and CD4 +/CD8 + in patients in active stage were lower than those in patients in non-active stage,while NF-κB protein,IRF-3 protein,IRF-7 protein and RIG-I protein were higher than those in patients in non-active stage(P<0.01).CD4 + T cells,CD8 + T cells,and CD4 +/CD8 + were negatively correlated with NF-κB protein,IRF-3 protein,IRF-7 protein and RIG-I protein in dermatomyositis group and patients in active stage(P<0.01).There was no correlation of CD4 + T cells,CD8 + T cells,and CD4 +/CD8 + with NF-κB protein,IRF-3 protein,IRF-7 protein and RIG-I protein in control group and patients in non-active stage(P>0.05).Conclusion In patients with dermatomyositis,peripheral blood CD4 + T cells,CD8 + T cells,CD4 +/CD8 + are decreased,while RIG-I pathway activity is increased,both of which are related to disease activity.In addition,peripheral blood T lymphocytes and RIG-I pathway have negative regulatory effects,which may play an interaction in the occurrence and disease activity of dermatomyositis.
Keywords：DermatomyositisT lymphocytesCD4 +CD8 +CD4 +/CD8 +Pathway nuclear factor-κBInter-feron regulatory factor-3Correlation
Publication Date：2023-12-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 345-349 )