Effect and Safety of Tripterygium Wilfordii Multiglucoside Combined with Bailing Capsule on Inflammatory Factors in Patients with Stage Ⅳ Diabetic Nephropathy
ZUO Jianjiao
WEI Xuan
SHI Yuntao
LI Yuchan
LI Gang
WANG Jin
Abstract：Objective To explore the effect and safety of Tripterygium wilfordii multiglucoside combined with Bailing capsule on inflammatory factors in patients with stageⅣdiabetic nephropathy.Methods Seventy patients with stageⅣdia-betic nephropathy with normal renal function treated from January 2017 to June 2021 were selected and divided into Bailing group(n =35)and combination group(n =35)according to different treatment methods.The conventional treatment group was given Bailing capsule,and the combination group was given Tripterygium wilfordii multiglucoside combined with Bailing capsule.The changes of serum inflammatory factors,liver function and white blood cell(WBC)count before and after treat-ment were observed.Results After treatment,the serum levels of interleukin-1β(IL-1β),interleukin-6(IL-6),tumor nec-rosis factor-α(TNF-α)and C reactive protein(CRP)in the two groups were lower than those before treatment,and lower in the combination group than in the Bailing group(P＜0.05).After treatment,the serum albumin level in the two groups was higher than that before treatment,and higher in combination group than in the Bailing group(P＜0.05).After treatment,there was no significant difference in serum aspartate aminotransferase,alanine transferase and WBC count between the two groups(P＞0.05).Conclusion Tripterygium wilfordii multiglucoside combined with Bailing capsule in the treatment of stageⅣdiabetic nephropathy can significantly improve the inflammatory state of patients,and has no significant effect on liver function and WBC count,with good safety.
Keywords：Diabetic nephropathiesTripterygium wilfordii multiglucosideBailing capsulesInterleukin-6C reac-tive proteinAlbuminAlanine transaminaseWhite blood cell
Publication Date：2023-10-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 231-234 )