Clinical Observation of Jiawei Zhenwu Decoction Combined with Amioda-rone in the Treatment of Patients with Bradyarrhythmia
WAN Dongmei
ZHAO Yukai
HAO Xuedong
ZHAI Wenji
GAO Jing
XU Qian
Abstract：Objective To investigate the effects of Jiawei Zhenwu Decoction combined with Amiodarone on inflamma-tory indexes and expression of cyclic adenosine monophosphate(cAMP)/protein kinase A(PKA)signaling pathway-related proteins in patients with bradyarrhythmia(BA).Methods A total of 80 patients with BA treated from December 2021 to De-cember 2022,diagnosed as palpitations of Yang deficiency of heart and kidney by traditional Chinese medicine,were selected and divided into research group(n =40)and control group(n =40)according to random number table method.The control group was treated with Amiodarone,and the research group was treated with Jiawei Zhenwu decoction.The clinical efficacy and incidence of adverse reactions of the two groups were observed,and the heart rate,TCM syndrome score,inflammatory in-dicators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C reactive protein(hs-CRP)]and cAMP/PKA signaling pathway-related proteins were compared between the two groups before and after treatment.Results The total effective rate of the research group was 97.50％(39/40),which was significantly higher than that of the control group[77.50％(31/40)](P＜0.01).After treatment,the mean heart rate,the minimum heart rate,24 h heart rate and cAMP protein and PKA protein expressions in the two groups were higher than those before treatment,and higher in the research group than in the control group(P＜0.05).After treatment,the scores of each syndrome of palpitation,fatigue,chest tight-ness and shortness of breath and the levels of serum TNF-α,IL-6 and hs-CRP in the two groups were lower than those before treatment,and lower in the research group than in the control group(P＜0.05).There was no significant difference in the in-cidence of adverse reactions between the two groups(P＞0.05).Conclusion Jiawei Zhenwu decoction combined with Ami-odarone can improve the therapeutic effect of BA,improve bradycardia and clinical symptoms,reduce the level of inflammato-ry indicators,and regulate the expression of cAMP/PKA signaling pathway-related proteins,with good safety.
Keywords：BradyarrhythmiaJiawei Zhenwu decoctionAmiodaroneHeart rateInterleukin-6SyndromeCyclic adenosine monophosphateProtein kinase A
Publication Date：2023-10-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 225-230 )