Efficacy of probiotic products on serum lipid profiles:a meta-analysis
WANG Li
ZHU Zhiming
SHEN Yating
LIU Yanbo
FANG Zhirong
Abstract：Objective To evaluate the efficacy of probiotic products on human serum lipid profiles, we conducted a meta-analysis. Methods Randomized, controlled clinical trials relating to interventional studies of probiotic products on human serum lipid profiles were obtained by search of electronic databases, such as PubMed, Cochrane Library, Web of Science, EMBASE, Chinses Pe-riodical Full Text Database, Wanfang Database, Full Text Database of Chinese Sci-Tech Periodical. Statistical analysis was performed with Review Manager 5. 3. 3. Results Eighteen randomized con-trolled trials were analyzed in our study. Meta-analysis results showed that the serum total cholesterol [mean difference(MD)=-0. 2 mmol/L, 95％ confidence intervals(CI): -0. 28— -0. 12 mmol/L] and low-density lipoprotein cholesterol ( MD=-0. 19 mmol/L, 95％CI:-0. 26 —-0. 13 mmol/L) were significantly decreased ( P<0. 00001) in probiotic intervention group compared with the placebo group, while high-density lipoprotein cholesterol and triglyceride had no significant differ-ence ( P>0. 05) . Patients with hyperlipidemia, overweight ( body weight index was 25—29. 9 kg/m2), receiving long-term intervention duration (>4 weeks) and intestinal micro-ecologic products got more benefit. Conclusion The probiotic products were effective in down-regulating the serum total cholesterol and low-density lipoprotein cholesterol levels in dyslipidemia patients and healthy in-dividuals. It is expected to be used in the primary and secondary prevention of atherosclerotic cardio-vascular diseases in patients with dyslipidemia.
Keywords：HyperlipidemiasProbioticsRandomized controlled trialsMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 159-166 )