Therapeutic effect of teprenone combined with beraprost sodium in chronic atrophic gastritis without Helicobacter pylori infection
SHENG Xiaoyan
PENG Chaosheng
TIAN Li
WANG Yu
YANG Lu
Xia Jing
Abstract：Objective To investigate the therapeutic effect of teprenone combined with beraprost sodium in chronic atrophic gastritis (CAG) without Helicobacter pylori infection. Methods The survey was conducted in 120 subjects selected from our hospital between February 2012 and May 2016. Based on the diagnostic criteria of CAG, the subjects were divided into two groups: observation group (n = 60) and control group (n = 60). The control group was treated with teprenone, while the observation group was treated with compound beraprost sodium and teprenone. The curative efficacy, improvement of clinical symptoms, pathological changes of the gastric mucosa and adverse drug reaction were observed and compared. Results After treatment, the observation group had a total semiotic effective rate of 91.7％, which was significantly higher than that in the control group(75.0％) (P＜0.05). The pathological improvement rate in observation group (81.7％) was significantly higher than that in contral group (65.0％) (P ＜ 0.05). The adverse drug reaction of two groups had no statistically significant difference. Conclusion Combined teprenone with beraprost sodium in treating CAG without Helicobacter pylori infection is effective, and can significantly improve clinical symptoms and gastric mucosal lesions.
Keywords：TeprenoneBeraprost sodiumChronic atrophic gastritis (CAG)
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 35-38 )