Clinical significance of the cyclin-dependent kinase 10 gene promoter methylation in breast cancer
LI Wenmei
LIU Jiajia
ZHANG Yinpo
LU Jianrong
Abstract：Objective To investigate the methylation status of the cyclin-dependent kinase 10 ( CDK10) gene promoter in breast cancer. Methods Methylation-specific polymerase chain re-action was performed to observe CDK10 gene promoter methyation in 50 cases of breast cancer ti-ssues companied with their adjacent non-cancerous tissues. The relationship between CDK10 gene methyation and clinical pathological parameters were also analyzed. Results Methylated CDK10 gene was frequently observed in 60. 0% (30/50) of primary tumors,but not in any normal tissue. CDK10 gene methylation was significantly correlated with lymph node metastasis and TNM staging of tumors ( P<0. 05) . Conclusion CDK10 gene methylation may possess a significant function in the development of breast cancer.
Keywords：Cyclin-dependent kinase 10 ( CDK10)DNA methylationBreast cancer
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-21,31 )