Hypertension and cognitive dysfunction
DONG Zhiyu
LI Yunxia
Abstract：Constant hypertension at midlife is one of the important risk factors of cognitive dysfunction . The relationship between antihypertensive therapy and cognitive dysfunction is uncertain and needs further research. And other abnormal blood press such as increased pulse pressure, high nocturnal blood press level, nondipper status and exaggerated blood press variability is relative to cognitive dysfunction. From pathological point, hypertension can stimulate the growth of vascular smooth muscle cells and cause vascular remodeling. Then the reduced vascular regulatory capacity results in brain hypoperfusion and cognitive dysfunction. From imaging point, hypertension can not only faciliate the age factors on the structure of the brain, but also change the cerebral structures without the influence of the age factors. Many cross-sectional studies of the relationship between anti-hypertension and cognition found conflicting relationships with positive, negative and U-shaped asso-ciations. But the majority of longitudinal studies have found elevated blood pressure to be associated with cognitive decline. We search the word hypertension, cognitive dysfunction, antihypertensive agents as keywords in Pubmed and make a review about the connection among hypertension, antihy-pertension, structural change in the brain, functional change in vascular and cognitive dysfunction.
Keywords：HypertensionCognitive dysfunctionAntihypertensive therapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 308-311 )