Clinical application of autologous bone marrow mesenchymal stem cell transplantation in children with Down syndrome
LIU Fang
YANG Hui
WANG Zaoyan
QU Suqing
Abstract：Objective To observe the clinical efficacy of transplantation with autologous bone marrow mesenchymal stem cells ( BMMSCs) in the treatment of children with Down syndrome. Methods Fifty-one children with Down syndrome ( 0. 5—7 years old ) , admitted to our hospital from November 2012 to November 2014, were chosen;Autologous bone marrow collected and sorted for BMMSCs by once right ventricle and twice lumbar puncture. Each time the number of cell trans-plantation is 1×106 /kg. Each child for assessment of Gesell mental and motor developments in the same time periods was performed 6 months before and 6 months after the autologous BMMSCs trans-plantation. Meanwhile, the improvement of each patient was followed up and analyzed by l, 3 and 6 months after the transplantation. Results One patient failed in follow-up; the other 50 were ob-served completely. Gradual mental and motor improvements appeared in these 32 patients 1 month after the transplantation, and lasted till the 6 months of transplantation. There are more improve ment in the fine motor, reactant and personal, social behavior in 6 months after transplantation ( P<0. 05) . Conclusion Autologous BMMSCs transplantation can improve the intellectual development in a short time, mainly in the fine motor, reactant and personal, social behavior in children with Down syndrome. BMMSCs transplantation for Down syndrome is safe and effective in a short-term.
Keywords：Bone marrow mesenchymal stem cell ( BMMSCs )TransplantationDown syn-drome
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 288-291 )