The research progress of stem cell aging mechanisms and the solution
WANG Wenjing
CHEN Xuxin
HAN Zhihai
Abstract：Self-renewal and multilineage differentiation of stem cell are thought to be the ideal seed cell, with strong repair capacity for injured tissues. However, such as any other somatic cells, stem cell is aging upon a long-term culture, then it will affect the treatment of disease. So, in order to ensure the best treatment of stem cell for disease, it is necessary to understand stem cell aging mechanisms. This review discuss the aging mechanisms of stem cell mainly from the telomerase sys-tem, Wnt/β-catenin signaling pathways, oxidative stress and so on, then we want to find the solu-tion in order to achieve the goal of delaying stem cell senescence and even reversing the aging.
Keywords：Stem cellAgingMechanismsAnti-aging
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 253-257 )