Serum free fatty acid metabolism and composition in type 2 diabetic mellitus patients with macrovascular complications

LI Zhe; WANG Ruiying; ZHANG Zhicheng

doi:10.3969/j.issn.2095-3097.2016.04.008

Abstract：Objective To discuss the relationship between the serum free fatty acid ( FFA) composition and macrovascular complications in type 2 diabetes mellitus ( T2DM) . Methods One hundred and seventy-three cases of T2DM patients in the second hospital of hebei medical university between December 2010 and January 2012 were selected, and divided into four groups. Group A, 36 cases, without macrovascular complications in T2DM patients, the age was (55. 7±5. 9) years old. Group B, 59 cases, with 1 kind of macrovascular complications in T2DM patients, the age was (56.7± 9. 7) years old. Group C, 58 cases, with 2 kinds of macrovascular complications in T2DM patients, the age was (58. 3±7. 4) years old. Group D, 20 cases, with 3 kinds of macrovascular complica-tions in T2DM patients, the age was (59. 8±8. 9) years old. Fourty one healthy people were com-pared as normal group, group N, the age of (54. 2±7. 4) years old. Tested the serum FFA content and composition by gas chromatography of external standard method. Results Levels of total fatty acids (TFA), saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA) in diabetes pa-tients were significantly higher than those in the healthy control ( P<0. 05) . The palmitic acid ( C16∶0), stearic acid (C18∶0), lignoceric acid (C24∶0) levels were significantly increased in the diabe-tes (C16∶0, C18∶0, P<0. 01, C24∶0 (P<0. 05). Oleic acid (C18∶1) level and linoleic acid ( C18∶2 ) level were significantly higher than the normals ( P<0. 05 ) . Docosahexaenoic acid level was decreased significantly ( P<0. 01) . The total fatty acids, C16∶0, C18∶0, C18∶1 levels in group A, group B, group C, group D were remarkable correlated with the severity of vascular lesions. Conclusion For type 2 diabetic patients, the change of free fatty acids component, as an early in-dex of lipid metabolic disorder, was closely related to large vascular lesions.