A randomized controlled study of different doses of hydromorphone and sufentanil for painless bronchoscopy
TIAN Ye
CAO Fuyang
LI Liang
XU Xiaobin
LI Jun
Abstract：Objective To determine the efficacy and safety of varied concentrations of hydro-morphone plus propofol sedation in bronchoscopy. Methods Eighty consecutive patients undergoing bronchoscopy were randomly allocated to receive sufentanil or varied concentrations of hydromor-phone (5μg/kg, 10μg/kg or 15μg/kg) with 20 patients in each group. MAP, HR, SpO2 and RR were compared among groups before anesthesia induction ( T0 ) , 1 min post induction ( T1 ) , intra-operative period ( T2 ) and at the end of procedure ( T3 ) . Duration of operation, recovery times, VAS and satisfaction ratings were recorded. Intraoperative movement and cough, hypoxemia, postope-rative vomitting, dizziness, and pruritus were monitored and compared among groups. Results At the time point of T2 and T3 , MAP and HR were higher in H1 group compared with SF, H2 or H3 group. RR and SpO2 were lower in SF and H3 groups than those in the H1 and H2 groups at T1 . There was a longer recovery time in SF group compared with H1, H2 or H3 group. Anesthetist satis-faction score was higher in H2 group than that in SF, H1 or H3 group, and VAS score was signifi-cantly higher in H1 group comparison with SF, H2 or H3 group. There was a lower incidence of intra-operative movement and cough in H1 group. The incidence of hypoxemia, postoperative vomitting and dizziness was significantly lower in H1 and H2 groups. SF group had a significantly higher inci-dence of postoperative pruritus than that in H1, H2 or H3 group. Conclusion Propofol plus 10μg/kg hydromorphone sedation was safe and feasible with stable circulation, lessened recovery time and decreased postoperative complications in patients undergoing flexible bronchoscopy.
Keywords：Flexible bronchoscopyHydromorphoneSufentanil
Publication Date：2016-01-01
Pages：3( 162-164 )