Clinical analysis of the effects of methylprednisolone on the treatment of refractory Mycoplasma pneumoniae pneumonia in children
FENG Xiaoqiang
GAO Chunyan
HU Xiaohong
LIU Shiping
Abstract：Objective To investigate the clinical efficacy of different dose of methylpred-nisolone for children with refractory Mycoplasma pneumoniae pneumonia ( RMPP ) . Methods Ninety children with RMPP, who were admitted to our hospital between September 2013 and August 2015, were allocated randomly into 3 groups: control group (antibiotics treatment, n=30), low dose methylprednisolone group [methylprednisolone 2 mg/(kg·d) and antibiotics, n=30], high dose methylprednisolone group [methylprednisolone 10 mg/(kg·d) and antibiotics, n=30]. Days that fever and respiratory symptom ( cough) recovery, length of hospitalization, chest CT or X ray recovery and adverse drug reactions were compared among the 3 groups. Results The symptom re-covery days and hospitalization days were shorter in the methylprednisolone groups than those in the control group;high dose methylprednisolone group were shorter than the low dose methylprednisolo-ne group. The differences were statistically significant ( P<0. 05 ) . After 2-weeks treatment, 20 ( 66. 7﹪) children in the high dose methylprednisolone group showed inflammation absorption in the iconography, while 16 (53. 3﹪) in the low dose methylprednisolone group, 5 (16. 7﹪) in the con-trol group ( P<0. 05 ) . There were no severe adverse events. Conclusion Methylprednisolone showed well efficacy in the treatment of the children with refractory Mycoplasma pneumoniae pneu-monia, high dose 10 mg/( kg·d) therapy was more effective than low dose 2 mg/( kg·d) therapy, with no more adverse drug reactions.
Keywords：PneumoniaMethylprednisoloneMycoplasma pneumoniae (MP)Children
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 92-95 )