Long term oral administration of low-dose glucocorticoids for prevention of multiple sclerosis recurrence:a case report and literature review
HUANG Xin
LIU Jianguo
QI Xiaokun
Abstract：Objective To analyze the safety and effectiveness of long-term oral administra-tion of low-dose glucocorticoids therapy on multiple sclerosis ( MS) and provide reference for therapy in remission stage of MS. Methods A retrospective analysis was performed evaluating one MS pa-tient in our hospital, who was given oral prednisolone acetate of 25 mg/d for 12 years. Clinical chara-cteristics and treatment details were analyzed and related literature was reviewed and discussed. Re-sults The patient had≥4 times of clinical recurrence (1996, 2002, 2003, 2015) and≥2 objec-tive clinical evidence (periventricular, juxta cortical, and cervical spinal cord), corresponding to RRMS diagnosis criteria. In remission period after the second attack long-term oral prednisolone ace-tate of 25 mg/d were taken without progression or deterioration ( except for recurrence after a cold in 2015) . No obvious adverse reaction happened. Conclusion Long term oral administration of low-dose glucocorticoids can be used as a safe and simple method for the prevention of recurrence of re-lapsing-remitting MS recurrence.
Keywords：Multiple sclerosis(MS)GlucocorticoidsTherapyRecurrencePrevention
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 38-41 )