Correlation between Toll-like receptor 9 gene polymorphism and myasthenia gravis
YUE Yaoxian
HONG Yu
WANG Shuxia
WANG Qi
ZHANG Xianjun
GAO Xiang
ZHANG Xu
LI Haifeng
Abstract：Objective To investigate the correlation between Toll-like receptor 9 ( TLR9 ) polymorphism and the susceptibility, severity and short-term effect of glucocorticoid in myasthenia gravis ( MG) patients. Methods One hundred and nine MG patients and 162 healthy controls in Han Chinese population were enrolled. Subgroups were divided by gender, onset age, thymoma sta-tus, Osserman type, Oosterhuis score and short-term effect of glucocorticoid. Rs352140 and rs187084 were genotyped by polymerase chain reaction-based restriction fragment length polymor-phism (PCR-RFLP) method. Allele frequencies and genotype frequencies (under codominant, log-additive and over-dominant mode of inheritance) were compared between MG/control group, MG subgroups/control group and each pairs of MG subgroups. Results In rs352140 and rs187084, there were no significant differences in allele frequencies and genotype frequencies ( under codomi-nant, log-additive and over-dominant mode of inheritance ) among MG/control group, MG sub-groups/control group and MG subgroups ( P>0. 05 ) . Conclusion No correlation was found be-tween rs352140 and rs187084 polymorphisms and the susceptibility, severity and short-term effect of glucocorticoid in myasthenia gravis patients.
Keywords：Myasthenia gravisToll like receptor 9(TLR9)Gene polymorphism
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 19-23 )