Comparison of two animal models ofhyperuricemi aand its complications
LIN Zhi jian
WANG Xuejie
ZHU Chunsheng
NIU Hongjuan
WANG Yu
ZHANG Bing
Abstract：Objective To compare the pathological differences of quail and rat hyperuricemia and complication models .Methods Model quails were fed with purine-rich diet .Model rats were fed with high fructose diet .Serum uric acid , triglyceride , glucose and metabolic enzymes including xanthine oxidase , hepaticlipase and lipoprotein lipase were detected .Results There was no differe-nce of body weight between groups ( P<0.05 ) .Serum uric acid levels were increased in purine-rich diet induced quail model , and triglyceride levels were increased in later period ( P<0.05 ) .Serum triglyceride levels were increased in high fructose diet induced rat model , uric acid levels were in-creased in later period ( P<0.05 ) .Serum xanthine oxidase activities were increased in quail model . Serum hepatic lipase activities were decreased in rat model .Conclusion Purine-rich diet and high fructose diet can induce quail or rat hyperurcemia combined with hypertriglyceridimia .There are some differences of the pathological features between the two animal models .
Keywords：HyperuricemiaHypertriglyceridimiaPurine-rich dietHigh fructose dietQuailRat
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 347-350 )