Role of inflammatory mediators in the pathogenesis of seawater drowning induced-acute lung injury
WANG Fan
HAN Zhihai
Abstract：Increasing importance has been attached to seawater drowning induced-acute lung injury (SWD-ALI) due to its rapid progression, complicated pathogenesis and ineffective therapy. Seawater aspiration caused by drowning can activate acute inflammatory response and release infla-mmatory related cells and factors, which can perform cascade reaction leading to partial inflammation in lung or systemic inflammatory response syndrome.A variety of inflammatory mediators participate initiation and enhancement of inflammatory response such as cytokines including tumor necrosis fac-tor-α( TNF-α) , interleukin ( IL)-1β, IL-6, IL-8, nuclear factor ( NF)-κB, neutrophils, reactive oxygens, proteases and so on.In this paper, the effect of inflammatory mediators on pathogenesis of SWD-ALI is reviewed.
Keywords：Seawater drowningAcute lung injuryInflammatory mediators
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 311-315 )