Study on traditional Chinese medicine-induced liver injury：from theory to clinical analysis
LI Xiuyu
LI Chaoqun
ZHANG Zhimin
WANG Xiaojing
YAO Xiangying
Abstract：Drug-induced liver injury (DILI) is a common clinical situation.The percentage of DILI cases goes up to about 0.46%— 1.08% in China, in which cases triggered by traditional Chinese medicine accounted for about 30%.To present the basic situation of traditional Chinese medicine-related liver damage and to provide a reference for the safe use in traditional Chinese medi-cine, relevant publications in recent decades are retrieved and searched in this article.According to the data, single Chinese herbs that tend to lead to liver damage mainly include dioscorea bulbifera L., tripchlorolide, minium, whereas compounds contain indignis naturalis pill, keyinwan, xiaohe pian and the traditional Chinese medicine decoction of xiao chaihu decoction.Toxic ingredients in tradi-tional Chinese medicine caused liver damage cover alkaloids, terpenoids, lactones and toxic plant protein elements.Symptoms of liver damage mainly involve digestive tract disturbances, liver dis-comfort, hepatomegaly, jaundice, higher transaminase, and the level of damage is closely related to the dosage.Traditional Chinese medicine-induced liver damage is mostly reversible, but severe cases may lead to death.Therefore, traditional Chinese medicine clinicians should have insights into mo-dern pharmacological research of traditional Chinese medicine and use traditional Chinese medicine with caution.If necessary, clinicians should regularly detect patient’s liver function in order to im-prove drug safety.
Keywords：Drug-induced liver injury (DILI)Traditional Chinese medicine
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 244-249 )