Advances in the development of nano targeted drug delivery systems for hydroxygcamptothecine
MA Ping
JIN Wulong
MA Liping
Abstract：The current formulations of the natural anti-cancer product hydroxycamptothecine display poor water solubility and stability , short half-life, adverse effects ( or toxicity ) , and many other issues to limit its clinical use .Nano targeted drug delivery systems have emerged in recent years and shown promising prospects in targeted drug delivery , controlling drug release , improving the bioavailability of poorly soluble drugs , and reducing side effects of toxic drugs .Thus, nano tar-geting drug delivery system has attracted considerable attention as a novel and potentially effective and safe approach to deliver a variety of drugs , particularly natural anti-cancer medicines including hydroxycamptothecin .This article reviews the recent status of various nano targeted and other drug delivery systems for hydroxycamptothecin , which are currently under investigation and development , and discusses their characteristics and theoretical benefits for future clinical applications .
Keywords：HydroxycamptothecineNanoparticlesDrug delivery system
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 185-189 )