The rlo es of matrix metla loproteinase and its inhibitors in the formation and growth process of cerebral aneurysm
KONG Xiangyi
WANG Renzhi
Abstract：Cerebral diseases is one of the commonest health hazards that severely threaten hu-man′s health, especially the aged more than 50 yrs old.And about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA).Therefore, exploring effective methods to de-crease CA′s incidence and reduce the effects of complications is of vital importance for maintaining-people′s health and extending the average human life span .It has been observed that the proteolytic activity , the expression of plasmin , membranetype-1 matrix metalloproteinase-1, and matrix metallo-proteinase-2 ( MMP-2) increased in aneurysm wall tissue that were all more than those in normal cerebral arteries .Moreover , MMP inhibitors such as doxycycline and statins may prohibit aneurysm formation and growth .MMP is involved in a lot of pathophysiology processes such as morphogenesis , angiogenesis , apoptosis and tissue repair .In this article , we reviewed the latest literatures and ex-plained in detail the roles of MMP and its inhibitors in the formation and growth process of CA .
Keywords：Cerebral aneurysmMatrix metalloproteinase ( MMP )Matrix metalloproteinase inhibitorsDoxycycline
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 129-132 )