The relationship between serum midkine level and insulin resistance in obesity patients with morning blood pressure surge

CAO Yuean; PENG Chaosheng; HE Jidong; XIA Jing; ZHANG Wenluo; YANG Lu; WANG Yu

doi:10?3969/j?issn?2095￣3097?2015?02?005

Abstract：Objective To investigate the relationship between serum midkine ( MK ) level and insulin resistance in obesity patients with morning blood pressure surge (MBPS). Methods Based on the results of 24 hours ambulatory blood pressure monitoring and body mass index( BMI),150 subjects with normal clinic blood pressure were divided into three groups, obesity with MBPS ( BMI≥25 kg/m2,MBPS≥35 mmHg) group ( n=42),single obesity ( BMI≥25 kg/m2,MBPS<35 mmHg)group (n=58) and healthy control (BMI<25 kg/m2, MBPS<35 mmHg) group (n=50) . The level of serum MK was detected by ELISA method. The fasting plasma glucose and fasting insulin were also detected. The insulin resistance was assessed by insulin resistance index ( HOMA￣IR) which was calculated by homeostasis model assessment. The levels of three groups′ serum MK were compared and the correlation of serum MK level and HOMA￣IR was analysed. Results ①The comparision of serum MK level showed:the serum MK level in obesity with MBPS group was signifi￣cantly higher compared with that in healthy control group and in single obesity group [(1?44±0?32) vs (0?86±0?11),(0?90±0?15) all P<0?01]. There was no significant difference in serum MK be￣tween single obesity group and healthy control group? ②The comparision of HOMA￣IR showed:HOMA￣IR in MBPS group was significantly higher compared with that in healthy control group and single obesity group [(5?23±0?96) vs(1?81±0?21), (2?72±0?37) all P<0?01]. HOMA￣IR in single obesity group was higher than that in healthy control group ( P<0?05) . ③Pearson correlation analysis indicated that the serum MK level was positively correlated with HOMA￣IR in MBPS group ( r=0?494,P<0?01 ) . Conclusion There was hyperinsulinemia and the level of serum MK was correlated with HOMA￣IR in obesity patients. MK and insulin resistance may be involved in the <br> occurrence and development of MBPS in obesity patients.