Pharmacokinetics changes of voriconazole in seawater immersed hypothermic rabbits
WANG Qiang
FENG Bo
ZHANG Yi
REN Tingling
Abstract：Objective To investigate the pharmacokinetic changes of voriconazole ( VOZ) in seawater immersed hypothermic rabbits .Methods Twenty healthy rabbits were randomly assigned to two groups ( n=10 ): hypothermic group and control group .Rabbits in hypothermic group were immersed into (21±1)℃seawater for 60 mins before administration.All the rabbits were adminis-tered a single oral dose of 10 mg/kg VOZ.The temperature and VOZ in plasma of the rabbits at different sampling time were determined .Pharmacokinetic parameters were calculated by 3P97 soft-ware .Results The temperature of hypothermic rabbits were declined during and after the seawater immersion, and back to normal at 36 h after immersion (36.6±0.8)℃.Pharmacokinetic of vorico-nazole was changed .Compared with rabbits in control group , half-life time ( t1/2 ) and ( clearances ) CLs of hypothermia rabbits were significantly reduced (P<0.05), but tmax, area under concentra-tion-time curve (AUC0-t), and AUC0-∞ had no significant difference (P>0.05).Conclusion Clearance of voriconazole in seawater immersed hypothermia rabbits slowed down .
Keywords：Voriconazole(VOZ)PharmacokineticsHypothermia
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 216-219 )