Research progress of Yes-associated protein and p73 in malignant tumor
FU Minglei
DA Lintai
LI Wei
ZHANG Jinghui
Abstract：Yes-associated protein ( YAP ) is a major regulator of Hippo signal pathway , which can promote cell proliferation and inhibit apoptosis .YAP expressed in many malignant tumor , such as breast cancer , lung cancer , colon cancer , stomach cancer and ovarian cancer , and it was significantly up-regulated .On the other hand , as a transcriptional co-activator ,YAP enhanced tran-scription of p73 to promote the cell apoptosis when DNA damaged .The process of preserve and regu-lating the intracellular environment , YAP bring into the different play .In this review , we will briefly discuss the action of Hippo pathway , YAP and p73 in malignant tumors , the specific regulatory mechanisms and the function of YAP and p 73 in tumor development .
Keywords：Hippo signal pathwayYes-associated protein (YAP)p73 gene
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 198-201 )