Biological roles of CD39 in translational medicine
ZHANG Bo
ZHANG Jie
TAN Tao
ZHANG Hao
ZHU Hua
Abstract：Ectonucleoside triphosphate diphosphohydrolase 1 ( ENTPD-1, also known as CD39) is an integrated cell transmembrane protein , which can degrade extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) into adenosine.It is also a key regulator of purinergic modulation .This review is focused on the important roles of CD39 in ischemia reperfusion injury to multiple tissues , thrombosis, rejection reaction after organ transplation, tumor suppression, and cross-talk between these diseases.
Keywords：CD39Adenosine triphosphate ( ATP )AdenosineIschemia-reperfusionThrombosisGraft rejectionAnti-tumor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 180-183,192 )