Study on the development of podophyllotoxin related new drugs
XU Xiaohui
SUN Taoli
XU Lili
ZHU Yuting
Abstract：Podophyllotoxin is cyclolignolide that has some pharmacological activities , and it is known to have various functions and bioactivities such as antitumor , antivirus, anti-rheumatism and insecticide.Among them, the antitumor activity of podophyllotoxin is widely noted , so that it is taken as a lead compound in drug discovery of anticancer .However, there are some drawbacks, for example poor water solubility, easy to produce multidrug resistance and strong toxicity , these all li-mit its clinical application.So the focus of research is to find efficient and low toxicity of podophyllo -toxin derivatives through the structure modification .This paper introduces the pharmacophore model and quantitative structure activity relationships (QSAR) model of podophyllotoxin, and the research approach about its structure modification .
Keywords：PodophyllotoxinsPharmacophoreQuantitative structure activity relationships (QSAR)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 162-165 )