Study on the relationship between prolactin level and risk of breast cancer among pre-and postmenopausal women
WENG Xuefen
FANG Yusen
HUANG Xuchun
HUANG Binliang
ZHUANG Shanshan
HONG Chaoqun
Abstract：Objective To study the relationship between serum prolactin (PRL) levels and women breast cancer diagnosis .Method A total of 240 patients (breast cancer and breast benign hyperplasia) were recruited and divided into premenopausal breast cancer group ( RⅠ, 48 pa-tients), postmenopausal breast cancer group (RⅡ, 48 patients), premenopausal breast benign hy -perplasia group (ZⅠ, 88 patients) and postmenopausal breast benign hyperplasia group (ZⅡ, 56 patients).The electrochemical luminescence method was used to detect prolactin levels in peripheral venous blood serum.Results PRL level in group RⅠincreased obviously, and it was significantly higher than that of group RⅡ and group ZⅠ (P<0.001).The positive rate of PRL in group RⅠwas significantly higher than that of RⅡ and ZⅠ (P<0.001), but there was no significant diffe -rence between RⅡ and ZⅡ (P=0.776).The sensitivity (P<0.001) and accuracy (P=0.003) of PRL detection in premenopausal patients with breast cancer were higher than those in postmenopaus -al patients.Conclusion These results indicated that PRL contributed to the development of pre -menopausal breast cancer.Detection of serum PRL is helpful for early diagnosis and prevention of breast cancer in premenopausal women .
Keywords：Breast cancerProlactin (PRL)Serum markerPre-menopausalPost-menopausal
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 140-142 )