Chimeric antigen receptor for immunotherapy of cancer
WU Yuting
LIANG Huasheng
Abstract：Down-regulating the necessary component of immune system and suppressing pro-duction of immunosuppressive factors results in the tumor immune escape.Recently,the genetic modification of T cells with chimeric antigen receptors (CARs)was designed to solve the mechanism of escape immunosurveillance.The unique structure of CARs endows T cell tumor specific cytotoxici-ty and tumor antigen recognition ability.This adoptive antitumor immunotherapy develops rapidly and brings hope to the patients with tumors.
Keywords：Chimeric antigen receptors (CARs)Adoptive immunotherapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 108-111 )