The influence of pre-infusion with dexmedetomidine on the onset time and recovery time of rocuronium in total intravenous anesthesia
GE Shuaina
DAI Zhigang
LI Jun
Abstract：Objective To explore the influence of pre-infusion with dexmedetomidine on the onset time and recovery time of rocuronium in total intravenous anesthesia.Methods Fifty Ameri-can Society of Anesthesiolog (ASA)Ⅰand Ⅱpatients scheduled forendoscopic sinus surgery were included in this study.These patients were randomly divided into dexmedetomidine group (25 pa-tients)and control group (25 patients).Dexmedetomidine 1.0 μg/kg was intravenously infused 15 min prior to induction ofanesthesia in dexmedetomidine group (within 10 min).Equal volume of 0.9%saline were infused in control group.Anesthesia was induced with propofol and sufentanyl, then maintained with propofol and remifentanil.MAP,HR,SpO2 were monitored and recorded at the time points of pre-administration,administration completed immediately,immediately pre-intuba-tion,1 min,3 min and 5 min after intubation.Neuromuscular function was monitored using accelero-myography.The onset time and 25%,50%,75%,90%recovery time of rocuronium were recorded. Results The onset time of rocuroniumin dexmedetomidine group is shorter than that in the control group (P<0.05).There is no effect on the 25%,50%,75%,90%recovery time of rocuronium. Conclusion Dexmedetomidine prior to induction can shorten the onset time of rocuronium,but there was no effect on the recovery time of rocuronium.
Keywords：Total intravenous anesthesiaDexmedetomidineRocuroniumOnset timeRecovery time
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 105-107,111 )