Effect of the hypophosphatemia on the prognosis of patients receiving mechanical ventilation

SHUAI Weizheng; ZHANG Zhicheng; LI Dawei; ZOU Jianfeng; HU Zilong

doi:10.3969/j.issn.2095-3097.2014.02.006

Abstract：Objective This study investigated the effect of the concentration of serum phos-phate on the prognosis of patients with mechanical ventilation.Methods One hundred and fifty two patients receiving mechanical ventilation admitted to ICU from from January 1 st to December 3 1 st 2012 were enrolled.The patient′sage,gender,primary diseases,duration of without mechanical ventilation,length of ICU stay,simply acute physiology score Ⅱ(SAPSⅡ),acute physiology and chronic health evaluationⅡ(APACHEⅡ)score,clinical outcome,the lowest concentration of serum phosphate in first 24 hr and during hospital stay were recorded.All cases were divided into two groups according to the clinical outcome of the patients.Multiple logistic regression analyses and re-ceiver operating characteristic curve (ROC curve)were performed to assess the association between the factors and the mortality.Results Of the 152 cases analyzed,the overall mortality was 15.13%(23/152)within hospital stay.The results demonstrated that the rate of blood stream infection and acute stroke,APACHE Ⅱ score,expected mortality,SAPSⅡ score of the non-survival group were higher than these of survival group (P<0.05 ).The duration of without mechanical ventilation was shorter in the non-survival group (P<0.05).The lowest serum phosphate concentration in total hos-pital stay was higher in survival group (P<0.05 ).The multiple logistic regression analysis further indicated that the factors Pilow and APACHE Ⅱscore forecast a poor prognosis for the patients with mechanical ventilation.Conclusion The Pilow and APACHE Ⅱscore are correlated to the prognosis of patients receiving mechanical ventilation,they may serve as an mortality predictor in these pa-tients.