The research progress of a Aurora-A kinase and its inhibitors
XU Xiaohui
SUN Taoli
ZHU Yuting
Abstract：Aurora-A is an important member of Aurora kinase family,which plays a signifi-cant function in cell mitosis process.The overexpression of Aurora-A is closely associated with a va-riety of human tumors.Aurora-A is designed as a new target for anticancer drugs,owing to its major function in cell mitosis.At present,a few selective inhibitors of Aurora-A kinase have entered the clinical study and showed good therapeutic effect.In this article,we will state the biological proper-ties of Aurora-A kinase.At the same time,we will introduce the close relationship between Aurora-A kinase and tumor,and further outline the development status of Aurora-A kinase inhibitors.
Keywords：Aurora-AMitosisAntitumorKinase inhibitors
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 79-83 )