A case report of Q fever with liver injury diagnosed by metagenomics next-generation sequencing
MO Yingxin
WANG Ying
HUANG Yanfei
Abstract：Objective To investigate the etiological diagnosis of a case of Q fever by metagenomics next-generation sequencing(mNGS)and its clinical value.Methods Clinical data of the case were collected and organized,and an epidemiological investigation was conducted.Blood samples were collected for diagnosis by mNGS.Results Case analysis revealed that the patient had a history of contact with domestic dogs and tick bites at their hometown before the onset of illness.After returning to Shenzhen,the patient presented with recurrent fever of unknown origin.Upon admission for examination and treatment,mNGS confirmed the infection with Coxiella burnetii.Furthermore,CT scans,color Doppler ultrasound,and blood tests indicated the presence of liver injury in the patient.Conclusion Based on the epidemiological history,clinical symptoms,and laboratory test results,this case was diagnosed as Q fever complicated with liver injury.It highlights the important role of mNGS in the early identification and diagnosis of rare infections.
Keywords：Q feverCoxiella burnetiimetagenomics next-generation sequencingliver injury
Publication Date：2025-08-20
Online Publishing Date：2025-08-29(First online date of this platform, not the publication date of the document)
Pages：3( 496-498 )