Preparation of long-lasting mosquito repellent cream using controlled-release technology and its performance evaluation
XIANG Chunlan
XU Chengwei
HU Shasha
ZHANG Yinbing
Abstract：Objective To prepare diethyltoluamide(DEET)mosquito repellent cream with long-lasting mosquito repellent effect.Methods DEET was adsorbed by silica microspheres,and the adsorption effect was tested by scanning electron microscope(SEM),and the controlled-release effect after adsorption was tested by thermogravity and open volatilization method.The formulation of mosquito repellent cream was prepared using DEET,silica microspheres,and film forming agent polyester-5,and its mosquito repellent,waterproof and perspirant effect was tested.Results It was proved that the silica microspheres could significantly reduce the volatilization rate of DEET.It was found that both silica microspheres and film forming agent could prolong the protection duration.The combination of silica and polyester could provide synergistic effect,prolonging the protection duration to more than 60%,and provided the waterproof and anti-sweat effect.Conclusion This research provides a new method to extend mosquito repellent effectiveness,and the mosquito repellent effect of the formula added with silica microspheres and film forming agent reaches 9.8 hours,which can provide long-term and non-reapplying mosquito repellent protection for outdoor workers.
Keywords：silica microspherecontrolle-releaselong-lastingwaterproof
Publication Date：2025-08-20
Online Publishing Date：2025-08-29(First online date of this platform, not the publication date of the document)
Pages：4( 389-392 )