Predictive value of platelet/high density lipoprotein cholesterol ratio for prognosis of patients with acute ischemic stroke after endovascular interventional therapy
WANG Tingting
HU Pengfei
ZHOU Ziwei
MENG Wenjuan
LI Weiyue
Abstract：Objective To investigate the predictive value of platelet/high density lipoprotein cholesterol ratio(PHR)for the prognosis of patients with acute ischemic stroke after endovascular interventional therapy(EIT).Methods A total of 104 patients with acute ischemic stroke who underwent EIT(mechanical thrombectomy)at Xingtai Central Hospital/Affiliated Hospital of Xingtai Medical College from April 2023 to March 2025 were selected.After a 3-month follow-up,the modified Rankin Scale(mRS)was used to divide the patients into a good prognosis group(<3 points,n=43)and a poor prognosis group(≥3 points,n=61).The blood platelet count(PLT),high-density lipoprotein cholesterol(HDL-C),and PHR levels between the two groups were compared.Receiver operating characteristic(ROC)was applied to evaluate the predictive value of each indicator.Multivariate logistic stepwise regression was used to analyze the influencing factors of prognosis.Results PLT and PHR levels in the poor prognosis group were higher,whereas the HDL-C level in the poor prognosis group was lower(P<0.05).The AUC of predicting EIT prognosis in patients with acute ischemic stroke using PHR was 0.911(Z=8.269,P<0.001),which was higher than that of PLT(AUC=0.874,Z=7.334,P<0.001)and HDL-C prediction(AUC=0.762,Z=6.815,P<0.001).The proportion of patients with age≥60 years,history of diabetes,postoperative bleeding transformation in the poor prognosis group was higher than that in the good prognosis group,with a higher NIHSS score at admission(P<0.05).Multivariate analysis showed that high NIHSS score at admission(OR=2.323,95%CI:1.582～3.412),postoperative bleeding conversion(OR=2.662,95%CI:1.750～4.049),and high PHR(OR=2.901,95%CI:1.863～4.518)were independent risk factors for poor prognosis of EIT(P<0.05).Conclusions High PHR is associated with the risk of poor prognosis of EIT in patients with acute ischemic stroke,and can be used as a potential important marker to predict the prognosis of EIT.
Keywords：platelet-to-high-density lipoprotein cholesterol ratioacute ischemic strokeendovascular interventional therapyprognosis
Publication Date：2026-03-28
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：5( 65-69 )